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Current hepatitis B treatment guidelines and future research directions

Jonathan Skupsky,Ke-Qin Hu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 145-157 doi: 10.1007/s11684-014-0335-1

Abstract:

Hepatitis B virus (HBV) infection causes a tremendous clinical burden across the world with more than

Keywords： chronic hepatitis B     HBV treatment guidelines     APASL guidelines     EASL guidelines     AASLD guidelines    

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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 111-125 doi: 10.1007/s11684-021-0854-5

Abstract: in COVID-19 patients, the association of liver injury caused by specific subtype especially chronic hepatitisB (CHB) with COVID-19 has not been elucidated.

Keywords： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 135-144 doi: 10.1007/s11684-014-0331-5

Abstract:

Chronic hepatitis B is a major health problem in China.The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infectionThe most prevalent hepatitis B virus strains in China are genotypes B and C, whereas those in westernChronic hepatitis B poses a heavy burden to the society in China.

Keywords： chronic hepatitis B     epidemiology     prevention     treatment    

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Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 17-23 doi: 10.1007/s11684-014-0313-7

Abstract:

Chronic hepatitis B is a major health burden worldwide.antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronic hepatitisB.On the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitisB patients, this paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based

Keywords： chronic hepatitis B     therapeutic     antigen-antibody complexes     DNA     vaccine    

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Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 250-253 doi: 10.1007/s11684-014-0333-3

Abstract: The patient has suffered from hepatitis B for 30 years.Comprehensive treatments included effective inhibition of hepatitis B virus replication and intensive

Keywords： acute-on-chronic liver failure     submassive necrosis     viral hepatitis B     esophageal variceal bleeding     liver    

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Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 271-276 doi: 10.1007/s11684-009-0054-1

Abstract: The aim of this paper is to investigate the relationship between hepatitis B virus (HBV) DNA levels duringthe course and the progression to cirrhosis with chronic hepatitis B.A total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followedB e antigen, and γ-glutamyl transpeptidase at baseline were independent risk factors of cirrhosisProgression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up

Keywords： hepatitis B     chronic     viral load     liver cirrhosis    

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MicroRNAs and hepatitis viruses

Gang LI MD , Xiaojia XIONG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 265-270 doi: 10.1007/s11684-009-0055-0

Abstract: years, investigators gradually brought the concept of miRNA into studies of viral infection, including hepatitisThe hepatitis B and C viruses are common causes of liver disease worldwide.It is very difficult to cure chronic hepatitis due to drug resistance during antivirus therapy.Elucidating the mechanisms of virus-host interactions in hepatitis B and C is very important in diagnosisThis article reviews the current knowledge of viral hepatitis (B and C type) at the level of miRNA and

Keywords： microRNA     hepatitis B virus     hepatitis C virus    

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Current advances in the elimination of hepatitis B in China by 2030

Shuye Zhang, Fusheng Wang, Zheng Zhang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 490-501 doi: 10.1007/s11684-017-0598-4

Abstract:

With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leadingefficacious in suppressing HBV replication; however, it fails to completely cure patients with chronic hepatitisB and even requires lifelong treatment.Work is still needed to eliminate hepatitis B in China by 2030.

Keywords： HBV     CHB     biomarker     functional cure     coinfection    

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Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 502-508 doi: 10.1007/s11684-017-0590-z

Abstract:

Although the efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitisB, long-term therapy has been recommended due to the high frequency of off-therapy viral DNA reboundIn this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the lifeIn contrast to hepatitis B surface antigen (HBsAg) that can originate from either the cccDNA or the integratedB, to distinguish the “functional cure” characterized as serum HBsAg loss with or without

Keywords： chronic hepatitis B     serum HBV RNA     nucleos(t)ide analogs     virological response     para-functional cure    

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New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 129-134 doi: 10.1007/s11684-014-0339-x

Abstract:

Chronic hepatitis B virus (HBV) infection is a significant threat to public health and an enormousmutant becomes predominant in the viral population following elimination of the wild-type virus in duck hepatitisB virus-chronically infected animals.

Keywords： hepatitis B virus     chronic HBV infection     natural course     hepatitis B     seroconversion    

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Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular

Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 419-429 doi: 10.1007/s11684-010-0160-0

Abstract: The association of viral mutations and haplotypic carriages with mutations in the preS region of hepatitisB virus (HBV) genotypes B and C with hepatocellular carcinoma (HCC) is of great significance for theWe analyzed the preS sequences of HBV genotypes B and C from 1172 HBV-infected subjects including 231risks of HCC in genotype C, whereas these mutations were inversely associated with HCC in genotype B.

Keywords： hepatitis B virus     hepatocellular carcinoma     mutation     genotype     haplotype    

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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitisB virus mutations with hepatocellular carcinoma risk

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: binding site polymorphism at the IL-1A gene and its multiplicative interactions with hepatitisB virus (HBV) mutations in the risk of hepatocellular carcinoma (HCC).

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (    

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Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 399-411 doi: 10.1007/s11684-010-0170-y

Abstract: found that, in the development of hepatocellular carcinoma (HCC), β-catenin was correlated with hepatitisB virus (HBV) X gene encoded protein, which is essential for HBV infectivity and is a potential cofactorexpression levels of wild-type β-catenin and E-cadherin were decreased in HepG2 cells expressing hepatitisB virus X protein (HBx), accompanied by destabilization of adherens junction.

Keywords： hepatocellular carcinoma     hepatitis B virus X protein     β     -catenin     cell adhesion     E-cadherin     transcriptional    

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Construction and expression of hepatitis B virus vector encoding TC-tagged core protein

Yuanyuan LIN MD, Xiaoming CHENG MS, Yuhu SONG MD, Peiyuan LI MD, Ying CHANG MM, Jinjian YAO MD, Jusheng LIN MD, PhD, Li ZHOU PhD, Leiming XU PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 396-402 doi: 10.1007/s11684-009-0056-z

Abstract: However, the hepatitis B virus (HBV) particle, which is a compact virion with limited internal space,blot and enzyme-linked immunosorbent assay (ELISA) analysis showed that the TC-tagged core protein, hepatitisB surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) could be expressed in cells transfected

Keywords： hepatitis B virus     vector     tetracysteine tag     core protein    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitisB virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholic    

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Title Author Date Type Operation

Current hepatitis B treatment guidelines and future research directions

Jonathan Skupsky,Ke-Qin Hu

Journal Article

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

Journal Article

Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Journal Article

Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Journal Article

Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Journal Article

Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Journal Article

MicroRNAs and hepatitis viruses

Gang LI MD , Xiaojia XIONG MM ,

Journal Article

Current advances in the elimination of hepatitis B in China by 2030

Shuye Zhang, Fusheng Wang, Zheng Zhang

Journal Article

Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Journal Article

New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Journal Article

Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular

Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,

Journal Article

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitisB virus mutations with hepatocellular carcinoma risk

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Journal Article

Construction and expression of hepatitis B virus vector encoding TC-tagged core protein

Yuanyuan LIN MD, Xiaoming CHENG MS, Yuhu SONG MD, Peiyuan LI MD, Ying CHANG MM, Jinjian YAO MD, Jusheng LIN MD, PhD, Li ZHOU PhD, Leiming XU PhD,

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article